Pueraria mirifica and Receptor Downregulation: How to Avoid Supplement Plateau
Quick answer Pueraria mirifica may feel less effective over time when sustained phytoestrogen stimulation leads to receptor downregulation, reducing how strongly cells respond to the same dose. The article suggests that cycling, dose variation, and periodic breaks may help manage a supplement plateau, while also checking factors such as product consistency, timing, and absorption. Key
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